Ingredients With a Purpose

At Pure Nutrition, we base our ingredient dosages on clinical trial research to help you get the most out of every workout. Unlike many other supplement companies, we focus on quality over quantity—delivering fewer, more effective ingredients instead of overwhelming your body with unnecessary extras.

This streamlined approach can allow your body to better absorb and utilize what we put in—meaning you’ll start to feel the effects faster. Say goodbye to waiting 30 minutes for your pre-workout to kick in. With less for your system to process, our supplements can be easier on your stomach and less likely to cause gut discomfort.

As we like to say: Pure Nutrition gives you everything you need—and nothing you don’t.


PurCaf® Caffeine: 150-400 mg

Pure STIM is formulated with non-synthetic organic caffeine derived from green coffee beans (as PurCaf®).

1,3,7-trimethylxanthine is the molecular compound known as caffeine. This is an alkaline, organic substance derived from xanthine — a biologically important purine base found in many bodily tissues and fluids. Methylxanthines like caffeine and theobromine stimulate the central nervous system (CNS) and heart to promote wakefulness and motivation.
 

Numerous studies have shown that taking caffeine before exercise can significantly improve overall performance, largely by reducing the rate of perceived exertion [1]. Caffeine may also enhance endurance and strength by increasing fatty acid oxidation and sparing muscle glycogen [2].


Beta Alanine: 3000-6000 mg

Beta-alanine is a beta-amino acid that combines with L-histidine to form carnosine, a dipeptide. Supplementing with beta-alanine has been shown to elevate muscle carnosine levels, which are rapidly depleted during high-intensity exercise [3].

Carnosine, an endogenous dipeptide, acts as a buffer within muscle cells to help reduce the buildup of acidic byproducts from strenuous activity, such as lactate and hydrogen ions [4]. Increasing muscle carnosine levels through beta-alanine supplementation enables you to work out longer and more intensely.

Many pre-workout supplements contain beta-alanine, though often in ineffective doses. That’s why we included a full clinical dose of beta-alanine (5,000 mg) in every scoop of Pure STIM. Evidence-based benefits of beta-alanine include:

  • Delaying the onset of neuromuscular fatigue during intense exercise [5]

  • Enhancing overall muscle strength [6]

  • Boosting muscle endurance and total work capacity [7]

  • Supporting healthy protein formation and combating dysfunctional proteins [8]

  • Significantly increasing lean muscle mass as part of a structured resistance-training program [9]

Note: Beta-alanine may cause a temporary tingling sensation called paresthesia as the body adjusts to higher carnosine levels. This effect is harmless and gradually decreases with regular use.

 

L-Citrulline DL-Malate 2:1: 4000-6000 mg

L-citrulline is an amino acid naturally found in watermelon that plays an important role in kidney function. It's become a popular ingredient in pre-workout supplements due to its ability to boost nitric oxide levels [10]. When nitric oxide production increases, blood flow improves, allowing nutrients and oxygen to replenish muscle tissue more efficiently. Ultimately, this translates to greater muscle pumps and heightened energy levels.

Numerous studies have demonstrated the ergogenic effects of L-citrulline malate, the citrulline salt of malic acid, such as:

  • Improving strength, aerobic performance, and muscle endurance [11,12]

  • Enhancing muscle anabolism and reducing muscle catabolism [13]


L-Tyrosine: 500-2000 mg

Tyrosine is a non-essential amino acid and a precursor for epinephrine and dopamine. These chemicals primarily produce alertness, increased energy and improved mental focus.

L-tyrosine is a conditionally essential amino acid that serves as a precursor to dopamine and norepinephrine, two neurotransmitters that govern motivation and reward. 

Research shows that supplementing with L-tyrosine can significantly enhance cognitive performance, especially under acutely stressful situations (such as intense training) [14]. 

L-Tyrosine has also been shown to improve “cognitive flexibility,” meaning it can help you adapt to changing cognitive demands without letting extraneous thoughts take over [1].


L-Arginine: 500-2000 mg

L-Arginine is an amino acid synthesized from glutamine, glutamate, and proline via the intestinal-renal axis in humans. L-Arginine acts as a facilitator of nitrates, nitric oxide specifically. Increased nitric oxide affects the muscles in the walls of the arteries and veins [15,16,17]. It prevents the muscles from tightening and the walls from narrowing. As a result, blood flows more easily through the vessels this leads to an increased feeling of a “pump” or fullness of a muscle while exercising it [15,16,17].

L-Arginine is a commonly used supplement and we included a full clinical dose of L-arginine (2,000 mg) in every scoop of Pure STIM.

 

Pink Himalayan Salt: 200-400 mg

Proper salt and fluid intake supports rehydration and effective fluid distribution[18]. Higher sodium levels in the bloodstream draw water into blood vessels, boosting blood volume and enhancing vascularity or "pump" during exercise [19]. Consuming more sodium before exercise can also promote cell hypertrophy, increasing cell size without raising cell count [20].

 

 

References

  1.  C;, G. M. (n.d.). Caffeine and physiological responses to submaximal exercise: A meta-analysis. International journal of sports physiology and performance. https://pubmed.ncbi.nlm.nih.gov/28872376/

  2. Gutiérrez-Hellín J;Aguilar-Navarro M;Ruiz-Moreno C;Muñoz A;Varillas-Delgado D;Amaro-Gahete FJ;Del Coso J; (n.d.). Effect of caffeine intake on fat oxidation rate during exercise: Is there a dose-response effect?. European journal of nutrition. https://pubmed.ncbi.nlm.nih.gov/35972531/

  3. Blancquaert L;Everaert I;Missinne M;Baguet A;Stegen S;Volkaert A;Petrovic M;Vervaet C;Achten E;DE Maeyer M;DE Henauw S;Derave W; (n.d.). Effects of histidine and β-alanine supplementation on Human Muscle Carnosine Storage. Medicine and science in sports and exercise. https://pubmed.ncbi.nlm.nih.gov/28106620/

  4. Baguet A;Reyngoudt H;Pottier A;Everaert I;Callens S;Achten E;Derave W; (n.d.). Carnosine loading and washout in human skeletal muscles. Journal of applied physiology (Bethesda, Md. : 1985). https://pubmed.ncbi.nlm.nih.gov/19131472/

  5. Stout, J. R., Graves, B. S., Smith, A. E., Hartman, M. J., Cramer, J. T., Beck, T. W., & Harris, R. C. (2008, November 7). The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 years): A double-blind randomized study. Journal of the International Society of Sports Nutrition. https://pmc.ncbi.nlm.nih.gov/articles/PMC2585553/

  6. Hoffman J;Ratamess N;Kang J;Mangine G;Faigenbaum A;Stout J; (n.d.). Effect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes. International journal of sport nutrition and exercise metabolism. https://pubmed.ncbi.nlm.nih.gov/17136944/

  7. Hoffman JR;Ratamess NA;Faigenbaum AD;Ross R;Kang J;Stout JR;Wise JA; (n.d.). Short-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football players. Nutrition research (New York, N.Y.). https://pubmed.ncbi.nlm.nih.gov/19083385/

  8. Babizhayev, M. A., Seguin, M. C., Gueyne, J., Evstigneeva, R. P., Ageyeva, E. A., & Zheltukhina, G. A. (1994, December 1). L-Carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. The Biochemical journal. https://pmc.ncbi.nlm.nih.gov/articles/PMC1137521/

  9. TL;, K. B. (n.d.). Effects of β-alanine supplementation on performance and body composition in collegiate wrestlers and football players. Journal of strength and conditioning research. https://pubmed.ncbi.nlm.nih.gov/21659893/

  10. Schwedhelm E;Maas R;Freese R;Jung D;Lukacs Z;Jambrecina A;Spickler W;Schulze F;Böger RH; (n.d.-a). Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: Impact on nitric oxide metabolism. British journal of clinical pharmacology. https://pubmed.ncbi.nlm.nih.gov/17662090/

  11. Alvares TS;Conte CA;Paschoalin VM;Silva JT;Meirelles Cde M;Bhambhani YN;Gomes PS; (n.d.). Acute L-arginine supplementation increases muscle blood volume but not strength performance. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. https://pubmed.ncbi.nlm.nih.gov/22251130/

  12. PM;, P.-G. J. (n.d.). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. Journal of strength and conditioning research. https://pubmed.ncbi.nlm.nih.gov/20386132/

  13. Figueroa A;Jaime SJ;Morita M;Gonzales JU;Moinard C; (n.d.). L-citrulline supports vascular and muscular benefits of exercise training in older adults. Exercise and sport sciences reviews. https://pubmed.ncbi.nlm.nih.gov/32568925/

  14. Hase A;Jung SE;aan het Rot M; (n.d.). Behavioral and cognitive effects of tyrosine intake in Healthy Human Adults. Pharmacology, biochemistry, and behavior. https://pubmed.ncbi.nlm.nih.gov/25797188/

  15. Hariri, L. (2023, August 14). Vasodilators. StatPearls [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK554423/

  16. Kurhaluk, N. (2023, May 3). The effectiveness of L-arginine in clinical conditions associated with hypoxia. International journal of molecular sciences. https://pmc.ncbi.nlm.nih.gov/articles/PMC10179183/

  17. Pahlavani, N., Entezari, M. H., Nasiri, M., Miri, A., Rezaie, M., Bagheri-Bidakhavidi, M., & Sadeghi, O. (2017, January 25). The effect of L-arginine supplementation on body composition and performance in male athletes: A double-blinded randomized clinical trial. Nature News. https://www.nature.com/articles/ejcn2016266

  18. BergeronMF, MulloyAL, FinnR, Pediatrics, A. A. of, Medicine, A. C. of S., González-AlonsoJ, HargreavesM, SawkaMN, ArmstrongLE, HillerWDB, SpeedyDB, GisolfiCV, ShirreffsSM, CostillDL, AllanJR, WengerCB, Heart, N., … BendaC. (2006, February 22). Heat cramps: Fluid and electrolyte challenges during tennis in the heat. Journal of Science and Medicine in Sport. https://www.sciencedirect.com/science/article/pii/S1440244003800051?via%3Dihub

  19. Gu JW;Anand V;Shek EW;Moore MC;Brady AL;Kelly WC;Adair TH; (n.d.). Sodium induces hypertrophy of cultured myocardial myoblasts and vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979). https://pubmed.ncbi.nlm.nih.gov/9576118/

  20. Valentine, C. author V. (n.d.). The importance of salt in the athlete’s diet : Current sports medicine reports. LWW. https://journals.lww.com/acsm-csmr/fulltext/2007/08000/the_importance_of_salt_in_the_athlete_s_diet.9.aspx#O4-9-3